Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/β-lactamase-type fold with highest structural similarit...

Bibliografiset tiedot
Päätekijät:	Valegård, K, Iqbal, A, Kershaw, N, Ivison, D, Généreux, C, Dubus, A, Blikstad, C, Demetriades, M, Hopkinson, R, Lloyd, A, Roper, D, Schofield, C, Andersson, I, McDonough, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2013

Samankaltaisia teoksia

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.
Tekijä: MacKenzie, A, et al.
Julkaistu: (2007)

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.
Tekijä: Arulanantham, H, et al.
Julkaistu: (2006)

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
Tekijä: Iqbal, A, et al.
Julkaistu: (2010)

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
Tekijä: Mackenzie, A, et al.
Julkaistu: (2010)

Chemistry and biosynthesis of clavulanic acid and other clavams.
Tekijä: Baggaley, K, et al.
Julkaistu: (1997)

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
Tekijä: Elkins, J, et al.
Julkaistu: (2005)

ISOLATION OF AN INTERMEDIATE IN CLAVULANIC ACID BIOSYNTHESIS
Tekijä: Baldwin, J, et al.
Julkaistu: (1990)

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
Tekijä: Kershaw, N, et al.
Julkaistu: (2002)

ISOLATION OF DIHYDROCLAVAMINIC ACID, AN INTERMEDIATE IN THE BIOSYNTHESIS OF CLAVULANIC ACID
Tekijä: Baldwin, J, et al.
Julkaistu: (1991)

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
Tekijä: Caines, M, et al.
Julkaistu: (2004)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
Tekijä: Schofield, C, et al.
Julkaistu: (2007)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
Tekijä: Sleeman, M, et al.
Julkaistu: (2005)

EXPRESSION IN ESCHERICHIA-COLI OF A CLAVAMINIC ACID SYNTHASE ISOZYME - A TRIFUNCTIONAL OXYGENASE INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
Tekijä: Lawlor, E, et al.
Julkaistu: (1994)

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Tekijä: Elkins, J, et al.
Julkaistu: (2002)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
Tekijä: Iqbal, A
Julkaistu: (2008)

The enzymes of β-lactam biosynthesis.
Tekijä: Hamed, R, et al.
Julkaistu: (2013)

The enzymes of beta-lactam biosynthesis
Tekijä: Hamed, R, et al.
Julkaistu: (2013)

The origin of the beta-lactam carbons of clavulanic acid
Tekijä: Thirkettle, J, et al.
Julkaistu: (1997)

Modulating carnitine levels by targeting its biosynthesis - selective inhibition of gamma-butyrobetaine hydroxylase
Tekijä: Rydzik, A, et al.
Julkaistu: (2014)

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Tekijä: Leung, I, et al.
Julkaistu: (2010)

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Tekijä: Leung, I, et al.
Julkaistu: (2010)

The enzymology of clavam and carbapenem biosynthesis.
Tekijä: Kershaw, N, et al.
Julkaistu: (2005)

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
Tekijä: Brown, R, et al.
Julkaistu: (1997)

Potassium clavulanate
Tekijä: Kotaro Fujii, et al.
Julkaistu: (2010-08-01)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
Tekijä: Hewitson, K, et al.
Julkaistu: (2007)

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
Tekijä: Clifton, I, et al.
Julkaistu: (2006)

Serotonin syndrome induced by amoxicillin–clavulanic acid
Tekijä: L. Naya Ríos, et al.
Julkaistu: (2024-04-01)

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease
Tekijä: Pettinati, I, et al.
Julkaistu: (2018)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
Tekijä: McDonough, M, et al.
Julkaistu: (2003)

13 C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions
Tekijä: Lohans, C, et al.
Julkaistu: (2017)

Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosis.
Tekijä: Cheng, A, et al.
Julkaistu: (2008)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
Tekijä: Lancaster, D, et al.
Julkaistu: (2004)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
Tekijä: Aik, W, et al.
Julkaistu: (2014)

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Tekijä: Aik, W, et al.
Julkaistu: (2014)

Amoxycillin-clavulanic acid treatment of melioidosis.
Tekijä: Suputtamongkol, Y, et al.
Julkaistu: (1991)

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
Tekijä: Brown, R, et al.
Julkaistu: (1996)

Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis.
Tekijä: Suputtamongkol, Y, et al.
Julkaistu: (1994)

Environmental Factors Modulate the Role of <i>orf21</i> Sigma Factor in Clavulanic Acid Production in <i>Streptomyces Clavuligerus</i> ATCC27064
Tekijä: Luisa F. Patiño, et al.
Julkaistu: (2022-02-01)

Therapeutic potential of combination antimicrobial drug amoxycillin/clavulanate in children
Tekijä: V. N. Drozdov, et al.
Julkaistu: (2020-07-01)

In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.
Tekijä: Santosh K Srivastava, et al.
Julkaistu: (2019-01-01)