Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/β-lactamase-type fold with highest structural similarit...

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Detalles Bibliográficos
Main Authors: Valegård, K, Iqbal, A, Kershaw, N, Ivison, D, Généreux, C, Dubus, A, Blikstad, C, Demetriades, M, Hopkinson, R, Lloyd, A, Roper, D, Schofield, C, Andersson, I, McDonough, M
Formato: Journal article
Idioma:English
Publicado: 2013

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