Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/β-lactamase-type fold with highest structural similarit...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Valegård, K, Iqbal, A, Kershaw, N, Ivison, D, Généreux, C, Dubus, A, Blikstad, C, Demetriades, M, Hopkinson, R, Lloyd, A, Roper, D, Schofield, C, Andersson, I, McDonough, M
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2013

Những quyển sách tương tự

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.
Bằng: MacKenzie, A, et al.
Được phát hành: (2007)

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.
Bằng: Arulanantham, H, et al.
Được phát hành: (2006)

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
Bằng: Iqbal, A, et al.
Được phát hành: (2010)

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
Bằng: Mackenzie, A, et al.
Được phát hành: (2010)

Chemistry and biosynthesis of clavulanic acid and other clavams.
Bằng: Baggaley, K, et al.
Được phát hành: (1997)

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
Bằng: Elkins, J, et al.
Được phát hành: (2005)

ISOLATION OF AN INTERMEDIATE IN CLAVULANIC ACID BIOSYNTHESIS
Bằng: Baldwin, J, et al.
Được phát hành: (1990)

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
Bằng: Kershaw, N, et al.
Được phát hành: (2002)

ISOLATION OF DIHYDROCLAVAMINIC ACID, AN INTERMEDIATE IN THE BIOSYNTHESIS OF CLAVULANIC ACID
Bằng: Baldwin, J, et al.
Được phát hành: (1991)

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
Bằng: Caines, M, et al.
Được phát hành: (2004)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
Bằng: Schofield, C, et al.
Được phát hành: (2007)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
Bằng: Sleeman, M, et al.
Được phát hành: (2005)

EXPRESSION IN ESCHERICHIA-COLI OF A CLAVAMINIC ACID SYNTHASE ISOZYME - A TRIFUNCTIONAL OXYGENASE INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
Bằng: Lawlor, E, et al.
Được phát hành: (1994)

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Bằng: Elkins, J, et al.
Được phát hành: (2002)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
Bằng: Iqbal, A
Được phát hành: (2008)

The enzymes of β-lactam biosynthesis.
Bằng: Hamed, R, et al.
Được phát hành: (2013)

The enzymes of beta-lactam biosynthesis
Bằng: Hamed, R, et al.
Được phát hành: (2013)

The origin of the beta-lactam carbons of clavulanic acid
Bằng: Thirkettle, J, et al.
Được phát hành: (1997)

Modulating carnitine levels by targeting its biosynthesis - selective inhibition of gamma-butyrobetaine hydroxylase
Bằng: Rydzik, A, et al.
Được phát hành: (2014)

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Bằng: Leung, I, et al.
Được phát hành: (2010)

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Bằng: Leung, I, et al.
Được phát hành: (2010)

The enzymology of clavam and carbapenem biosynthesis.
Bằng: Kershaw, N, et al.
Được phát hành: (2005)

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
Bằng: Brown, R, et al.
Được phát hành: (1997)

Potassium clavulanate
Bằng: Kotaro Fujii, et al.
Được phát hành: (2010-08-01)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
Bằng: Hewitson, K, et al.
Được phát hành: (2007)

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
Bằng: Clifton, I, et al.
Được phát hành: (2006)

Serotonin syndrome induced by amoxicillin–clavulanic acid
Bằng: L. Naya Ríos, et al.
Được phát hành: (2024-04-01)

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease
Bằng: Pettinati, I, et al.
Được phát hành: (2018)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
Bằng: McDonough, M, et al.
Được phát hành: (2003)

13 C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions
Bằng: Lohans, C, et al.
Được phát hành: (2017)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
Bằng: Lancaster, D, et al.
Được phát hành: (2004)

Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosis.
Bằng: Cheng, A, et al.
Được phát hành: (2008)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
Bằng: Aik, W, et al.
Được phát hành: (2014)

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Bằng: Aik, W, et al.
Được phát hành: (2014)

Amoxycillin-clavulanic acid treatment of melioidosis.
Bằng: Suputtamongkol, Y, et al.
Được phát hành: (1991)

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
Bằng: Brown, R, et al.
Được phát hành: (1996)

Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis.
Bằng: Suputtamongkol, Y, et al.
Được phát hành: (1994)

Environmental Factors Modulate the Role of <i>orf21</i> Sigma Factor in Clavulanic Acid Production in <i>Streptomyces Clavuligerus</i> ATCC27064
Bằng: Luisa F. Patiño, et al.
Được phát hành: (2022-02-01)

Therapeutic potential of combination antimicrobial drug amoxycillin/clavulanate in children
Bằng: V. N. Drozdov, et al.
Được phát hành: (2020-07-01)

In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.
Bằng: Santosh K Srivastava, et al.
Được phát hành: (2019-01-01)