Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
The beta cell KATP channel is an octameric complex of four pore-forming subunits (Kir6.2) and four regulatory subunits (SUR1). A truncated isoform of Kir6.2 (Kir6.2DeltaC26), which expresses independently of SUR1, shows intrinsic ATP sensitivity, suggesting that this subunit is primarily responsible...
Hauptverfasser: | Trapp, S, Proks, P, Tucker, S, Ashcroft, F |
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Format: | Journal article |
Sprache: | English |
Veröffentlicht: |
1998
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