Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

The beta cell KATP channel is an octameric complex of four pore-forming subunits (Kir6.2) and four regulatory subunits (SUR1). A truncated isoform of Kir6.2 (Kir6.2DeltaC26), which expresses independently of SUR1, shows intrinsic ATP sensitivity, suggesting that this subunit is primarily responsible...

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Main Authors:	Trapp, S, Proks, P, Tucker, S, Ashcroft, F
格式:	Journal article
语言:	English
出版:	1998

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