Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

The beta cell KATP channel is an octameric complex of four pore-forming subunits (Kir6.2) and four regulatory subunits (SUR1). A truncated isoform of Kir6.2 (Kir6.2DeltaC26), which expresses independently of SUR1, shows intrinsic ATP sensitivity, suggesting that this subunit is primarily responsible...

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Những tác giả chính: Trapp, S, Proks, P, Tucker, S, Ashcroft, F
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1998