Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators.

BACKGROUND: The original report of a possible association between myocardial infarction and the insertion/deletion (I/D) polymorphism of the gene for the angiotensin-1-converting enzyme (ACE) indicated a risk ratio for myocardial infarction with the DD genotype of 1.34 (95% CI 1.05-1.70), and the as...

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Bibliographic Details
Main Authors: Keavney, B, McKenzie, C, Parish, S, Palmer, A, Clark, S, Youngman, L, Delépine, M, Lathrop, M, Peto, R, Collins, R
Format: Journal article
Language:English
Published: 2000