Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.
Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages. At a finer scale, we de...
Автори: | Huang, P, Keller, C, Giardine, B, Grevet, J, Davies, J, Hughes, J, Kurita, R, Nakamura, Y, Hardison, R, Blobel, G |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
Cold Spring Harbour Laboratory Press
2017
|
Схожі ресурси
Схожі ресурси
-
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points
за авторством: Elisabeth F. Heuston, та інші
Опубліковано: (2018-05-01) -
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.
за авторством: Flint, J, та інші
Опубліковано: (2001) -
Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression
за авторством: Panagiotis Antoniou, та інші
Опубліковано: (2022-11-01) -
CLIMB: High-dimensional association detection in large scale genomic data
за авторством: Hillary Koch, та інші
Опубліковано: (2022-11-01) -
Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements
за авторством: Dowen, Jill M., та інші
Опубліковано: (2014)