Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

Proteolytic activity of separase is required for chiasma resolution during meiosis I in mouse oocytes. Rec8, the meiosis-specific alpha-kleisin subunit of cohesin, is a key target of separase in yeast. Is the equivalent protein also a target in mammals? We show here that separase cleaves mouse Rec8...

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Dades bibliogràfiques
Autors principals:	Kudo, N, Anger, M, Peters, A, Stemmann, O, Theussl, H, Helmhart, W, Kudo, H, Heyting, C, Nasmyth, K
Format:	Journal article
Idioma:	English
Publicat:	2009

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