Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although the literature is inconsistent. The aim of this study was to investigate possible associati...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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Wiley
2017
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| _version_ | 1797058372277633024 |
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| author | Raaschou-Nielsen, O Pedersen, M Stafoggia, M Weinmayr, G Andersen, Z Galassi, C Sommar, J Forsberg, B Olsson, D Oftedal, B Krog, N Aasvang, G Pyko, A Pershagen, G Korek, M De Faire, U Pedersen, N Östenson, C Fratiglioni, L Sørensen, M Eriksen, K Tjønneland, A Peeters, P Bueno-de-Mesquita, B Plusquin, M Key, T Jaensch, A Nagel, G Föger, B Wang, M Tsai, M Grioni, S Marcon, A Krogh, V Ricceri, F Sacerdote, C Migliore, E Tamayo, I Amiano, P Dorronsoro, M Sokhi, R Kooter, I de Hoogh, K Beelan, R Eeftens, M Vermeulen, R Vineis, P Brunekreef, B Hoek, G |
| author_facet | Raaschou-Nielsen, O Pedersen, M Stafoggia, M Weinmayr, G Andersen, Z Galassi, C Sommar, J Forsberg, B Olsson, D Oftedal, B Krog, N Aasvang, G Pyko, A Pershagen, G Korek, M De Faire, U Pedersen, N Östenson, C Fratiglioni, L Sørensen, M Eriksen, K Tjønneland, A Peeters, P Bueno-de-Mesquita, B Plusquin, M Key, T Jaensch, A Nagel, G Föger, B Wang, M Tsai, M Grioni, S Marcon, A Krogh, V Ricceri, F Sacerdote, C Migliore, E Tamayo, I Amiano, P Dorronsoro, M Sokhi, R Kooter, I de Hoogh, K Beelan, R Eeftens, M Vermeulen, R Vineis, P Brunekreef, B Hoek, G |
| author_sort | Raaschou-Nielsen, O |
| collection | OXFORD |
| description | Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although the literature is inconsistent. The aim of this study was to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10, PM2.5, PMcoarse, PM2.5 absorbance (soot)) and nitrogen oxides (NO2, NOx), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR=1.57 (95%CI: 0.81-3.01) per 5μg/m3 PM2.5 and HR=1.36 (95%CI: 0.84-2.19) per 10-5m-1 PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. This study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer. |
| first_indexed | 2024-03-06T19:49:35Z |
| format | Journal article |
| id | oxford-uuid:23814629-269b-4143-8958-18fbd5f9183f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:49:35Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:23814629-269b-4143-8958-18fbd5f9183f2022-03-26T11:44:48ZOutdoor air pollution and risk for kidney parenchyma cancer in 14 European cohortsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:23814629-269b-4143-8958-18fbd5f9183fSymplectic Elements at OxfordWiley2017Raaschou-Nielsen, OPedersen, MStafoggia, MWeinmayr, GAndersen, ZGalassi, CSommar, JForsberg, BOlsson, DOftedal, BKrog, NAasvang, GPyko, APershagen, GKorek, MDe Faire, UPedersen, NÖstenson, CFratiglioni, LSørensen, MEriksen, KTjønneland, APeeters, PBueno-de-Mesquita, BPlusquin, MKey, TJaensch, ANagel, GFöger, BWang, MTsai, MGrioni, SMarcon, AKrogh, VRicceri, FSacerdote, CMigliore, ETamayo, IAmiano, PDorronsoro, MSokhi, RKooter, Ide Hoogh, KBeelan, REeftens, MVermeulen, RVineis, PBrunekreef, BHoek, GSeveral studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although the literature is inconsistent. The aim of this study was to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10, PM2.5, PMcoarse, PM2.5 absorbance (soot)) and nitrogen oxides (NO2, NOx), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR=1.57 (95%CI: 0.81-3.01) per 5μg/m3 PM2.5 and HR=1.36 (95%CI: 0.84-2.19) per 10-5m-1 PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. This study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer. |
| spellingShingle | Raaschou-Nielsen, O Pedersen, M Stafoggia, M Weinmayr, G Andersen, Z Galassi, C Sommar, J Forsberg, B Olsson, D Oftedal, B Krog, N Aasvang, G Pyko, A Pershagen, G Korek, M De Faire, U Pedersen, N Östenson, C Fratiglioni, L Sørensen, M Eriksen, K Tjønneland, A Peeters, P Bueno-de-Mesquita, B Plusquin, M Key, T Jaensch, A Nagel, G Föger, B Wang, M Tsai, M Grioni, S Marcon, A Krogh, V Ricceri, F Sacerdote, C Migliore, E Tamayo, I Amiano, P Dorronsoro, M Sokhi, R Kooter, I de Hoogh, K Beelan, R Eeftens, M Vermeulen, R Vineis, P Brunekreef, B Hoek, G Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title | Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title_full | Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title_fullStr | Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title_full_unstemmed | Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title_short | Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts |
| title_sort | outdoor air pollution and risk for kidney parenchyma cancer in 14 european cohorts |
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