Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with hi...
Main Authors: | Findlay, J, Castro-Giner, F, Makino, S, Rayner, E, Kartsonaki, C, Cross, W, Kovac, M, Ulahannan, D, Palles, C, Gillies, R, MacGregor, T, Church, D, Maynard, N, Buffa, F, Cazier, J, Graham, T, Wang, L, Sharma, R, Middleton, M, Tomlinson, I |
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Format: | Journal article |
Language: | English |
Published: |
Nature Publishing Group
2016
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