Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with hi...

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Huvudupphovsmän: Findlay, J, Castro-Giner, F, Makino, S, Rayner, E, Kartsonaki, C, Cross, W, Kovac, M, Ulahannan, D, Palles, C, Gillies, R, MacGregor, T, Church, D, Maynard, N, Buffa, F, Cazier, J, Graham, T, Wang, L, Sharma, R, Middleton, M, Tomlinson, I
Materialtyp: Journal article
Språk:English
Publicerad: Nature Publishing Group 2016

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