Mapping trends in insecticide resistance phenotypes in African malaria vectors
Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2020
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| _version_ | 1797058430952800256 |
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| author | Hancock, PA Hendriks, CJM Tangena, J-A Gibson, H Hemingway, J Coleman, M Gething, PW Cameron, E Bhatt, S Moyes, CL |
| author_facet | Hancock, PA Hendriks, CJM Tangena, J-A Gibson, H Hemingway, J Coleman, M Gething, PW Cameron, E Bhatt, S Moyes, CL |
| author_sort | Hancock, PA |
| collection | OXFORD |
| description | Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations. We use 6,423 observations of the prevalence of resistance to the most important vector control insecticides to inform a Bayesian geostatistical ensemble modelling approach, generating fine-scale predictive maps of resistance phenotypes in mosquitoes from the Anopheles gambiae complex across Africa. Our models are informed by a suite of 111 predictor variables describing potential drivers of selection for resistance. Our maps show alarming increases in the prevalence of resistance to pyrethroids and DDT across sub-Saharan Africa from 2005 to 2017, with mean mortality following insecticide exposure declining from almost 100% to less than 30% in some areas, as well as substantial spatial variation in resistance trends. |
| first_indexed | 2024-03-06T19:50:27Z |
| format | Journal article |
| id | oxford-uuid:23cbbe1d-87bf-48e1-96dd-bd89096f6457 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:50:27Z |
| publishDate | 2020 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:23cbbe1d-87bf-48e1-96dd-bd89096f64572022-03-26T11:46:17ZMapping trends in insecticide resistance phenotypes in African malaria vectorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:23cbbe1d-87bf-48e1-96dd-bd89096f6457EnglishSymplectic ElementsPublic Library of Science 2020Hancock, PAHendriks, CJMTangena, J-AGibson, HHemingway, JColeman, MGething, PWCameron, EBhatt, SMoyes, CLMitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations. We use 6,423 observations of the prevalence of resistance to the most important vector control insecticides to inform a Bayesian geostatistical ensemble modelling approach, generating fine-scale predictive maps of resistance phenotypes in mosquitoes from the Anopheles gambiae complex across Africa. Our models are informed by a suite of 111 predictor variables describing potential drivers of selection for resistance. Our maps show alarming increases in the prevalence of resistance to pyrethroids and DDT across sub-Saharan Africa from 2005 to 2017, with mean mortality following insecticide exposure declining from almost 100% to less than 30% in some areas, as well as substantial spatial variation in resistance trends. |
| spellingShingle | Hancock, PA Hendriks, CJM Tangena, J-A Gibson, H Hemingway, J Coleman, M Gething, PW Cameron, E Bhatt, S Moyes, CL Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title | Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title_full | Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title_fullStr | Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title_full_unstemmed | Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title_short | Mapping trends in insecticide resistance phenotypes in African malaria vectors |
| title_sort | mapping trends in insecticide resistance phenotypes in african malaria vectors |
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