The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

Recognition of antigen by cytotoxic T lymphocytes (CTL) is determined by interaction of both the T cell receptor and its CD8 coreceptor with peptide-major histocompatibility complex (pMHC) class I molecules. We examine the relative roles of these receptors in the activation of human CTL using mutati...

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Hlavní autoři: Purbhoo, M, Boulter, J, Price, D, Vuidepot, A, Hourigan, C, Dunbar, P, Olson, K, Dawson, S, Phillips, R, Jakobsen, B, Bell, J, Sewell, A
Médium: Journal article
Jazyk:English
Vydáno: 2001

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