Rapid Y degeneration and dosage compensation in plant sex chromosomes
The nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed to reveal large-scale gene degeneration on plant Y chromosomes. Here, we uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, that ev...
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Journal article |
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National Academy of Sciences
2015
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| _version_ | 1826263417635209216 |
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| author | Papadopulos, A Chester, M Ridout, K Filatov, D |
| author_facet | Papadopulos, A Chester, M Ridout, K Filatov, D |
| author_sort | Papadopulos, A |
| collection | OXFORD |
| description | The nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed to reveal large-scale gene degeneration on plant Y chromosomes. Here, we uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, that evolved sex chromosomes de novo in the last 10 million years. Previous transcriptome-based studies of this species missed unexpressed, degenerate Y-linked genes. To identify sex-linked genes, regardless of their expression, we sequenced male and female genomes of S. latifolia and integrated the genomic contigs with a high-density genetic map. This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupted by premature stop codons. This contrasts with X-linked genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in males. Loss of functional Y-linked genes is partly compensated for by gene-specific up-regulation of X-linked genes. Our results demonstrate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals, and that the evolutionary trajectories of sex chromosomes are similar in the two kingdoms. |
| first_indexed | 2024-03-06T19:51:26Z |
| format | Journal article |
| id | oxford-uuid:241b8206-95fd-4367-b219-67ebca9214a8 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:51:26Z |
| publishDate | 2015 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:241b8206-95fd-4367-b219-67ebca9214a82022-03-26T11:48:04ZRapid Y degeneration and dosage compensation in plant sex chromosomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:241b8206-95fd-4367-b219-67ebca9214a8Symplectic Elements at OxfordNational Academy of Sciences2015Papadopulos, AChester, MRidout, KFilatov, DThe nonrecombining regions of animal Y chromosomes are known to undergo genetic degeneration, but previous work has failed to reveal large-scale gene degeneration on plant Y chromosomes. Here, we uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, that evolved sex chromosomes de novo in the last 10 million years. Previous transcriptome-based studies of this species missed unexpressed, degenerate Y-linked genes. To identify sex-linked genes, regardless of their expression, we sequenced male and female genomes of S. latifolia and integrated the genomic contigs with a high-density genetic map. This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupted by premature stop codons. This contrasts with X-linked genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in males. Loss of functional Y-linked genes is partly compensated for by gene-specific up-regulation of X-linked genes. Our results demonstrate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals, and that the evolutionary trajectories of sex chromosomes are similar in the two kingdoms. |
| spellingShingle | Papadopulos, A Chester, M Ridout, K Filatov, D Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title | Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title_full | Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title_fullStr | Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title_full_unstemmed | Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title_short | Rapid Y degeneration and dosage compensation in plant sex chromosomes |
| title_sort | rapid y degeneration and dosage compensation in plant sex chromosomes |
| work_keys_str_mv | AT papadopulosa rapidydegenerationanddosagecompensationinplantsexchromosomes AT chesterm rapidydegenerationanddosagecompensationinplantsexchromosomes AT ridoutk rapidydegenerationanddosagecompensationinplantsexchromosomes AT filatovd rapidydegenerationanddosagecompensationinplantsexchromosomes |