Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D
The asymmetric synthesis of the highly functionalized (3R,5R,6R)-3,6-diamino-5-hydroxyheptanoic acid, the key amino acid fragment of sperabillins B and D, was achieved by an asymmetric Michael addition of lithium (R)-(α-methylbenzyl)allylamide 10 to (E,E)-2,5-heptadienoate establishing the C-3 stere...
| Autores principales: | , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
1999
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| _version_ | 1826263426895183872 |
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| author | Davies, S Ichihara, O |
| author_facet | Davies, S Ichihara, O |
| author_sort | Davies, S |
| collection | OXFORD |
| description | The asymmetric synthesis of the highly functionalized (3R,5R,6R)-3,6-diamino-5-hydroxyheptanoic acid, the key amino acid fragment of sperabillins B and D, was achieved by an asymmetric Michael addition of lithium (R)-(α-methylbenzyl)allylamide 10 to (E,E)-2,5-heptadienoate establishing the C-3 stereogenic centre, the information from which was propagated to the C-5 and C-6 centres by a highly stereoselective iodocyclocarbamation reaction. |
| first_indexed | 2024-03-06T19:51:35Z |
| format | Journal article |
| id | oxford-uuid:2425d624-7cec-4548-84b5-30c2d6fe9e4c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:51:35Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:2425d624-7cec-4548-84b5-30c2d6fe9e4c2022-03-26T11:48:22ZAsymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and DJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2425d624-7cec-4548-84b5-30c2d6fe9e4cEnglishSymplectic Elements at Oxford1999Davies, SIchihara, OThe asymmetric synthesis of the highly functionalized (3R,5R,6R)-3,6-diamino-5-hydroxyheptanoic acid, the key amino acid fragment of sperabillins B and D, was achieved by an asymmetric Michael addition of lithium (R)-(α-methylbenzyl)allylamide 10 to (E,E)-2,5-heptadienoate establishing the C-3 stereogenic centre, the information from which was propagated to the C-5 and C-6 centres by a highly stereoselective iodocyclocarbamation reaction. |
| spellingShingle | Davies, S Ichihara, O Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title | Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title_full | Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title_fullStr | Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title_full_unstemmed | Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title_short | Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D |
| title_sort | asymmetric synthesis of a highly functionalized beta amino acid the key amino acid of sperabillins b and d |
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