Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D

Asymmetric synthesis of a highly functionalized beta-amino acid: the key amino acid of sperabillins B and D

The asymmetric synthesis of the highly functionalized (3R,5R,6R)-3,6-diamino-5-hydroxyheptanoic acid, the key amino acid fragment of sperabillins B and D, was achieved by an asymmetric Michael addition of lithium (R)-(α-methylbenzyl)allylamide 10 to (E,E)-2,5-heptadienoate establishing the C-3 stere...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Davies, S, Ichihara, O
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1999

Eitemau Tebyg

Total asymmetric synthesis of sperabillins B and D.
gan: Davies, S, et al.
Cyhoeddwyd: (2003)

ASYMMETRIC-SYNTHESIS OF SYN-ALPHA-ALKYL-BETA-AMINO ACIDS
gan: Davies, S, et al.
Cyhoeddwyd: (1994)

Asymmetric total synthesis of sperabillins B and D via lithium amide conjugate addition.
gan: Davies, S, et al.
Cyhoeddwyd: (2004)

Asymmetric synthesis of beta-amino acids via the Michael addition of chiral metal amides
gan: Davies, S, et al.
Cyhoeddwyd: (1997)

Asymmetric synthesis of beta-amino acid scaffolds
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Cyhoeddwyd: (2001)

Homochiral lithium amides for the asymmetric synthesis of beta-amino acids
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Cyhoeddwyd: (2006)

Asymmetric synthesis of beta-fluoroaryl-beta-amino acids
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The use of lithium (alpha-methylbenzyl)allylamide for the asymmetric synthesis of unsaturated beta-amino acid derivatives
gan: Davies, S, et al.
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The asymmetric synthesis of beta-haloaryl-beta-amino acid derivatives
gan: Bull, S, et al.
Cyhoeddwyd: (2000)

Asymmetric synthesis of beta-pyridyl-beta-amino acid derivatives
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Cyhoeddwyd: (2002)

Asymmetric synthesis of beta-haloaryl beta-amino acid derivatives
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Cyhoeddwyd: (2001)

ASYMMETRIC-SYNTHESIS OF ANTI-ALPHA-ALKYL-BETA-AMINO ACIDS
gan: Davies, S, et al.
Cyhoeddwyd: (1994)

ASYMMETRIC-SYNTHESIS OF R-BETA-AMINO BUTANOIC ACID AND S-BETA-TYROSINE - HOMOCHIRAL LITHIUM AMIDE EQUIVALENTS FOR MICHAEL ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS
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Cyhoeddwyd: (1991)

ASYMMETRIC-SYNTHESIS OF BETA-AMINO-ALPHA-HYDROXY ACIDS VIA DIASTEREOSELECTIVE HYDROXYLATION OF HOMOCHIRAL BETA-AMINO ENOLATES
gan: Bunnage, M, et al.
Cyhoeddwyd: (1994)

Asymmetric syntheses of (+)-negamycin, (+)-3-epi-negamycin and sperabillin C via lithium amide conjugate addition
gan: Davies, S, et al.
Cyhoeddwyd: (2011)

AN ASYMMETRIC-SYNTHESIS OF N-PROTECTED BETA-AMINO ALDEHYDES AND BETA-AMINO KETONES
gan: Davies, S, et al.
Cyhoeddwyd: (1995)

Asymmetric synthesis of homochiral differentially protected bis-beta-amino acid scaffolds
gan: Bull, S, et al.
Cyhoeddwyd: (2002)

Parallel synthesis of homochiral beta-amino acids
gan: Davies, S, et al.
Cyhoeddwyd: (2007)

Asymmetric synthesis of alpha-mercapto-beta-amino acid derivatives: application to the synthesis of polysubstituted thiomorpholines
gan: Candela-Lena, J, et al.
Cyhoeddwyd: (2006)

ASYMMETRIC AMINO-ACID SYNTHESIS - PREPARATION OF THE BETA-ANION DERIVED FROM ASPARTIC-ACID
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

Asymmetric synthesis of N-protected syn and anti (E)-3-amino-2-hydroxy-4-hexenoate: A practical method for the C-alpha epimerization of anti beta-amino-alpha-hydroxy acids
gan: Brackenridge, I, et al.
Cyhoeddwyd: (1999)

ASYMMETRIC-SYNTHESIS OF (-)-(1R,2S)-CISPENTACIN AND RELATED CIS-2-AMINO AND TRANS-2-AMINO CYCLOPENTANE-1-CARBOXYLIC AND CYCLOHEXANE-1-CARBOXYLIC ACIDS
gan: Davies, S, et al.
Cyhoeddwyd: (1994)

Asymmetric synthesis of a homochiral differentially protected pseudo-meso bis-beta-amino acid scaffold
gan: Bull, S, et al.
Cyhoeddwyd: (2001)

Enantioselective synthesis of beta-amino acids /
gan: Juaristi, Eusebio, et al.
Cyhoeddwyd: (2005)

Trading N and O: asymmetric syntheses of beta-hydroxy-alpha-amino acids via alpha-hydroxy-beta-amino esters
gan: Davies, S, et al.
Cyhoeddwyd: (2013)

Asymmetric synthesis and applications of beta-amino Weinreb amides: asymmetric synthesis of (S)-coniine.
gan: Burke, A, et al.
Cyhoeddwyd: (2004)

ASYMMETRIC-SYNTHESIS OF (2S,3R)-3-AMINO-2-HYDROXYDECANOIC ACID - THE UNKNOWN AMINO-ACID COMPONENT OF MICROGININ
gan: Bunnage, M, et al.
Cyhoeddwyd: (1994)

ASYMMETRIC-SYNTHESIS OF ANTI-ALPHA-ALKYL-BETA-AMINO CARBOXAMIDES
gan: Davies, S, et al.
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Asymmetric synthesis of alpha-amino carbonyls (aldehydes, ketones and acids) using lithium (R)-N-benzyl-N-alpha-methylbenzylamide
gan: Davies, S, et al.
Cyhoeddwyd: (2001)

LITHIUM (ALPHA-METHYLBENZYL)ALLYLAMIDE - A DIFFERENTIALLY PROTECTED CHIRAL AMMONIA EQUIVALENT FOR THE ASYMMETRIC-SYNTHESIS OF BETA-AMINO ACIDS AND BETA-LACTAMS
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NON-PROTEINOGENIC AMINO-ACID SYNTHESIS - SYNTHESIS OF BETA, GAMMA-UNSATURATED ALPHA-AMINO-ACIDS FROM ASPARTIC-ACID
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Cyhoeddwyd: (1989)

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics
gan: Matthias Wünsch, et al.
Cyhoeddwyd: (2017-11-01)

Asymmetric synthesis of beta2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.
gan: Beddow, J, et al.
Cyhoeddwyd: (2007)

SYNTHESIS OF NONPROTEINOGENIC AMINO-ACIDS .2. PREPARATION OF A SYNTHETIC EQUIVALENT OF THE GAMMA-ANION SYNTHON FOR ASYMMETRIC AMINO-ACID SYNTHESIS
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Cyhoeddwyd: (1989)

NON-PROTEINOGENIC AMINO-ACID SYNTHESIS - THE BETA-ANION DERIVED FROM ASPARTIC-ACID, AND ITS APPLICATION TO ALPHA-AMINO-ACID SYNTHESIS
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Cyclic beta-amino acid derivatives: synthesis via lithium amide promoted tandem asymmetric conjugate addition-cyclisation reactions.
gan: Davies, S, et al.
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Asymmetric synthesis of cyclic beta-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis
gan: Chippindale, A, et al.
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Synthesis of tetrahydrofuran templated beta- and gamma-amino acid carbopeptoids.
gan: Watterson, M, et al.
Cyhoeddwyd: (2000)

Selective deprotection strategies to N-(alpha-methylbenzyl)-beta-amino esters and derived beta lactams
gan: Davies, S, et al.
Cyhoeddwyd: (1998)

Asymmetric syntheses of β- and γ-amino acids
gan: Zammit, C
Cyhoeddwyd: (2015)