Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.

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Nitric oxide, generated by the nitric oxide synthase (NOS) enzymes, plays pivotal roles in cardiovascular homeostasis and in the pathogenesis of cardiovascular disease. The NOS cofactor, tetrahydrobiopterin (BH4), is an important regulator of NOS function, since BH4 is required to maintain enzymatic...

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Bibliografiske detaljer
Main Authors:	Crabtree, M, Channon, K
Format:	Journal article
Sprog:	English
Udgivet:	2011

Lignende værker

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
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A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
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Regulation of eNOS function by tetrahydrobiopterin in vascular disease
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Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling.
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Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
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Recoupling the cardiac nitric oxide synthases: Tetrahydrobiopterin synthesis and recycling
af: Alkaitis, MS, et al.
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Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
af: Crabtree, M, et al.
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Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
af: Crabtree, M, et al.
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Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
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Tetrahydrobiopterin in cardiovascular health and disease.
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Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
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Endothelial cell tetrahydrobiopterin: going with the flow.
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Effects of endothelin-1 on intracellular tetrahydrobiopterin levels in vascular tissue
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Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension
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Troglitazone Stimulates the Insulin-induced Tetrahydrobiopterin Synthesis In Vascular Endothelial Cells
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A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance
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Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo
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Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells
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Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
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Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
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Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
af: Chuaiphichai, S, et al.
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Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
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Stimulation of Tetrahydrobiopterin Synthesis by Cyclosporin A during Lipopolysaccharide Treatment in Vascular Endothelial Cells
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303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
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Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
af: Schmidt, T, et al.
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Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
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GFRP tonically inhibits production of tetrahydrobiopterin and nitric oxide in marine endothelial cells
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Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases
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Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
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Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
af: Ali, Z, et al.
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The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
af: McNeill, E, et al.
Udgivet: (2012)