Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Nitric oxide, generated by the nitric oxide synthase (NOS) enzymes, plays pivotal roles in cardiovascular homeostasis and in the pathogenesis of cardiovascular disease. The NOS cofactor, tetrahydrobiopterin (BH4), is an important regulator of NOS function, since BH4 is required to maintain enzymatic...
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2011
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