Human genetic susceptibility to infectious disease.
Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Tog...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797058546785845248 |
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| author | Chapman, S Hill, A |
| author_facet | Chapman, S Hill, A |
| author_sort | Chapman, S |
| collection | OXFORD |
| description | Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence. |
| first_indexed | 2024-03-06T19:51:50Z |
| format | Journal article |
| id | oxford-uuid:2438aa07-5c14-4954-b05b-45ce4a665b3a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:51:50Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:2438aa07-5c14-4954-b05b-45ce4a665b3a2022-03-26T11:48:47ZHuman genetic susceptibility to infectious disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2438aa07-5c14-4954-b05b-45ce4a665b3aEnglishSymplectic Elements at Oxford2012Chapman, SHill, ARecent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence. |
| spellingShingle | Chapman, S Hill, A Human genetic susceptibility to infectious disease. |
| title | Human genetic susceptibility to infectious disease. |
| title_full | Human genetic susceptibility to infectious disease. |
| title_fullStr | Human genetic susceptibility to infectious disease. |
| title_full_unstemmed | Human genetic susceptibility to infectious disease. |
| title_short | Human genetic susceptibility to infectious disease. |
| title_sort | human genetic susceptibility to infectious disease |
| work_keys_str_mv | AT chapmans humangeneticsusceptibilitytoinfectiousdisease AT hilla humangeneticsusceptibilitytoinfectiousdisease |