Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation.
BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococc...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2011
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| _version_ | 1797058546978783232 |
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| author | Ibarz-Pavón, AB Maclennan, J Andrews, N Gray, S Urwin, R Clarke, S Walker, A Evans, MR Kroll, J Neal, K Ala'aldeen, D Crook, D Cann, K Harrison, S Cunningham, R Baxter, D Kaczmarski, E McCarthy, N Jolley, K Cameron, J Stuart, J Maiden, M |
| author_facet | Ibarz-Pavón, AB Maclennan, J Andrews, N Gray, S Urwin, R Clarke, S Walker, A Evans, MR Kroll, J Neal, K Ala'aldeen, D Crook, D Cann, K Harrison, S Cunningham, R Baxter, D Kaczmarski, E McCarthy, N Jolley, K Cameron, J Stuart, J Maiden, M |
| author_sort | Ibarz-Pavón, AB |
| collection | OXFORD |
| description | BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed. RESULTS: A total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear. CONCLUSIONS: Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction. |
| first_indexed | 2024-03-06T19:51:50Z |
| format | Journal article |
| id | oxford-uuid:2438ab64-0dd5-4f44-b5d2-99bd2284efe2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:51:50Z |
| publishDate | 2011 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:2438ab64-0dd5-4f44-b5d2-99bd2284efe22022-03-26T11:48:49ZChanges in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2438ab64-0dd5-4f44-b5d2-99bd2284efe2EnglishSymplectic Elements at OxfordOxford University Press2011Ibarz-Pavón, ABMaclennan, JAndrews, NGray, SUrwin, RClarke, SWalker, AEvans, MRKroll, JNeal, KAla'aldeen, DCrook, DCann, KHarrison, SCunningham, RBaxter, DKaczmarski, EMcCarthy, NJolley, KCameron, JStuart, JMaiden, M BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed. RESULTS: A total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear. CONCLUSIONS: Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction. |
| spellingShingle | Ibarz-Pavón, AB Maclennan, J Andrews, N Gray, S Urwin, R Clarke, S Walker, A Evans, MR Kroll, J Neal, K Ala'aldeen, D Crook, D Cann, K Harrison, S Cunningham, R Baxter, D Kaczmarski, E McCarthy, N Jolley, K Cameron, J Stuart, J Maiden, M Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title | Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title_full | Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title_fullStr | Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title_full_unstemmed | Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title_short | Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. |
| title_sort | changes in serogroup and genotype prevalence among carried meningococci in the united kingdom during vaccine implementation |
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