Low-dose aspirin for migraine prophylaxis.
The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial that studied low-dose aspirin (325 mg every other day) therapy among 22,071 US male physicians aged 40 to 84 years. Annual follow-up questionnaires requested information on the occurrence of numerous medical co...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1990
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| _version_ | 1797058562746220544 |
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| author | Buring, J Peto, R Hennekens, C |
| author_facet | Buring, J Peto, R Hennekens, C |
| author_sort | Buring, J |
| collection | OXFORD |
| description | The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial that studied low-dose aspirin (325 mg every other day) therapy among 22,071 US male physicians aged 40 to 84 years. Annual follow-up questionnaires requested information on the occurrence of numerous medical conditions including migraine. At the end of 60 months, morbidity follow-up was 99.7% complete, and the reported consumption of aspirin or other platelet-active drugs was 86% in the aspirin group and 14% in the placebo group. Of those randomized to aspirin, 661 (6.0%) reported migraine at some time after randomization, as compared with 818 (7.4%) of those allocated to the placebo group, representing a statistically significant 20% reduction in recurrence rate. The rate of self-report of ordinary headache was similar in the two groups. These data indicate that migraine is mediated, at least in part, by the effects of platelets and suggest that low-dose aspirin should be considered for prophylaxis among those with a history of established migraine. |
| first_indexed | 2024-03-06T19:52:03Z |
| format | Journal article |
| id | oxford-uuid:244add1c-d880-4214-8c19-7fce20d278a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:03Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:244add1c-d880-4214-8c19-7fce20d278a82022-03-26T11:49:12ZLow-dose aspirin for migraine prophylaxis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:244add1c-d880-4214-8c19-7fce20d278a8EnglishSymplectic Elements at Oxford1990Buring, JPeto, RHennekens, CThe Physicians' Health Study is a randomized, double-blind, placebo-controlled trial that studied low-dose aspirin (325 mg every other day) therapy among 22,071 US male physicians aged 40 to 84 years. Annual follow-up questionnaires requested information on the occurrence of numerous medical conditions including migraine. At the end of 60 months, morbidity follow-up was 99.7% complete, and the reported consumption of aspirin or other platelet-active drugs was 86% in the aspirin group and 14% in the placebo group. Of those randomized to aspirin, 661 (6.0%) reported migraine at some time after randomization, as compared with 818 (7.4%) of those allocated to the placebo group, representing a statistically significant 20% reduction in recurrence rate. The rate of self-report of ordinary headache was similar in the two groups. These data indicate that migraine is mediated, at least in part, by the effects of platelets and suggest that low-dose aspirin should be considered for prophylaxis among those with a history of established migraine. |
| spellingShingle | Buring, J Peto, R Hennekens, C Low-dose aspirin for migraine prophylaxis. |
| title | Low-dose aspirin for migraine prophylaxis. |
| title_full | Low-dose aspirin for migraine prophylaxis. |
| title_fullStr | Low-dose aspirin for migraine prophylaxis. |
| title_full_unstemmed | Low-dose aspirin for migraine prophylaxis. |
| title_short | Low-dose aspirin for migraine prophylaxis. |
| title_sort | low dose aspirin for migraine prophylaxis |
| work_keys_str_mv | AT buringj lowdoseaspirinformigraineprophylaxis AT petor lowdoseaspirinformigraineprophylaxis AT hennekensc lowdoseaspirinformigraineprophylaxis |