Selective inhibition of factor inhibiting hypoxia-inducible factor.
A set of four non-heme iron(II) and 2-oxoglutarate-dependent enzymes catalyze the post-translational modification of a transcription factor, hypoxia inducible factor (HIF), that mediates the hypoxic response in animals. Hydroxylation of HIF both causes its degradation and limits its activity. We des...
Những tác giả chính: | McDonough, M, McNeill, L, Tilliet, M, Papamicaël, C, Chen, Q, Banerji, B, Hewitson, K, Schofield, C |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2005
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