Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage.
In mammalian cells, S-phase DNA synthesis occurs at sites fixed to a sub-nuclear structure, the nuclear matrix or cage. This is an ordered network of non-histone proteins, which maintains its essential morphology even in the absence of DNA. We show here that unscheduled DNA synthesis following expos...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
1984
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| _version_ | 1826263481894043648 |
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| author | McCready, S Cook, P |
| author_facet | McCready, S Cook, P |
| author_sort | McCready, S |
| collection | OXFORD |
| description | In mammalian cells, S-phase DNA synthesis occurs at sites fixed to a sub-nuclear structure, the nuclear matrix or cage. This is an ordered network of non-histone proteins, which maintains its essential morphology even in the absence of DNA. We show here that unscheduled DNA synthesis following exposure of HeLa cells to ultraviolet light also takes place at this sub-structure. We also show that ultraviolet irradiation grossly reorganizes nuclear DNA, arresting S-phase synthesis at the cage and leaving the residual synthesis highly localized. |
| first_indexed | 2024-03-06T19:52:27Z |
| format | Journal article |
| id | oxford-uuid:24699fac-bb7b-4126-8e9c-514173f09a24 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:27Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:24699fac-bb7b-4126-8e9c-514173f09a242022-03-26T11:49:56ZLesions induced in DNA by ultraviolet light are repaired at the nuclear cage.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24699fac-bb7b-4126-8e9c-514173f09a24EnglishSymplectic Elements at Oxford1984McCready, SCook, PIn mammalian cells, S-phase DNA synthesis occurs at sites fixed to a sub-nuclear structure, the nuclear matrix or cage. This is an ordered network of non-histone proteins, which maintains its essential morphology even in the absence of DNA. We show here that unscheduled DNA synthesis following exposure of HeLa cells to ultraviolet light also takes place at this sub-structure. We also show that ultraviolet irradiation grossly reorganizes nuclear DNA, arresting S-phase synthesis at the cage and leaving the residual synthesis highly localized. |
| spellingShingle | McCready, S Cook, P Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title | Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title_full | Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title_fullStr | Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title_full_unstemmed | Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title_short | Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. |
| title_sort | lesions induced in dna by ultraviolet light are repaired at the nuclear cage |
| work_keys_str_mv | AT mccreadys lesionsinducedindnabyultravioletlightarerepairedatthenuclearcage AT cookp lesionsinducedindnabyultravioletlightarerepairedatthenuclearcage |