Intratumoural lymphatics in benign and malignant soft tissue tumours.
Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known. In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesi...
| Váldodahkkit: | , , , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
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2008
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| _version_ | 1826263484932816896 |
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| author | Mahendra, G Kliskey, K Williams, K Hollowood, K Jackson, D Athanasou, N |
| author_facet | Mahendra, G Kliskey, K Williams, K Hollowood, K Jackson, D Athanasou, N |
| author_sort | Mahendra, G |
| collection | OXFORD |
| description | Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known. In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin. Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma. Intratumoural lymphatics were also absent in most benign soft tissue tumours. Reparative and inflammatory soft tissue lesions contained lymphatics, as did all (pseudosarcomatous) proliferative myofibroblastic lesions including nodular, proliferative and ischaemic fasciitis, elastofibroma, nuchal fibroma and deep fibromatosis. Our results show that most soft tissue sarcomas do not contain intratumoural lymphatics, a finding which is consistent with the infrequent finding of sarcoma metastasis to lymph nodes. In contrast to fibrosarcoma and a number of other malignant spindle cell tumours, proliferative fibroblastic/myofibroblastic lesions of soft tissue contain intralesional lymphatic vessels. |
| first_indexed | 2024-03-06T19:52:30Z |
| format | Journal article |
| id | oxford-uuid:246d5553-c8e9-4dca-b694-3cfcffe09fed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:30Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:246d5553-c8e9-4dca-b694-3cfcffe09fed2022-03-26T11:50:00ZIntratumoural lymphatics in benign and malignant soft tissue tumours.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:246d5553-c8e9-4dca-b694-3cfcffe09fedEnglishSymplectic Elements at Oxford2008Mahendra, GKliskey, KWilliams, KHollowood, KJackson, DAthanasou, NSoft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known. In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin. Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma. Intratumoural lymphatics were also absent in most benign soft tissue tumours. Reparative and inflammatory soft tissue lesions contained lymphatics, as did all (pseudosarcomatous) proliferative myofibroblastic lesions including nodular, proliferative and ischaemic fasciitis, elastofibroma, nuchal fibroma and deep fibromatosis. Our results show that most soft tissue sarcomas do not contain intratumoural lymphatics, a finding which is consistent with the infrequent finding of sarcoma metastasis to lymph nodes. In contrast to fibrosarcoma and a number of other malignant spindle cell tumours, proliferative fibroblastic/myofibroblastic lesions of soft tissue contain intralesional lymphatic vessels. |
| spellingShingle | Mahendra, G Kliskey, K Williams, K Hollowood, K Jackson, D Athanasou, N Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title | Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title_full | Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title_fullStr | Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title_full_unstemmed | Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title_short | Intratumoural lymphatics in benign and malignant soft tissue tumours. |
| title_sort | intratumoural lymphatics in benign and malignant soft tissue tumours |
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