TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.

TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.

Stabilization of p53 in erythroid precursors in response to nucleosomal stress underlies the hypoplastic anemia in myelodysplastic syndromes (MDS) with chromosome 5q deletion [del(5q)]. We investigated whether cenersen, a clinically active 20-mer antisense oligonucleotide complementary to TP53 exon1...

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Bibliographic Details
Main Authors: Caceres, G, McGraw, K, Yip, B, Pellagatti, A, Johnson, J, Zhang, L, Liu, K, Fulp, W, Lee, J, Al Ali, N, Basiorka, A, Smith, L, Daugherty, F, Littleton, N, Wells, R, Sokol, L, Wei, S, Komrokji, R, Boultwood, J, List, A
Format: Journal article
Language:English
Published: 2013

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