Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib.

PURPOSE: A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). We sought to determine the dose of oral 6-(4-bromo-2-thienyl) methoxy purin-2-amine (lomeguatrib), a pseudosubstrate inactivator o...

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Hlavní autoři:	Watson, A, Sabharwal, A, Thorncroft, M, McGown, G, Kerr, R, Bojanic, S, Soonawalla, Z, King, A, Miller, A, Waller, S, Leung, H, Margison, G, Middleton, MR
Médium:	Journal article
Jazyk:	English
Vydáno:	2010

Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib.

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