The inverted neurogenetic gradient of the mammalian isocortex: development and evolution.
In this paper we review recent evidence on the molecular control of cell migration in the isocortex, and present an hypothesis for the evolutionary origin of the inside-out neurogenetic gradient of this structure. We suggest that there are at least two key factors involved in the acquisition of the...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797058600740323328 |
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| author | Aboitiz, F Morales, D Montiel, J |
| author_facet | Aboitiz, F Morales, D Montiel, J |
| author_sort | Aboitiz, F |
| collection | OXFORD |
| description | In this paper we review recent evidence on the molecular control of cell migration in the isocortex, and present an hypothesis for the evolutionary origin of the inside-out neurogenetic gradient of this structure. We suggest that there are at least two key factors involved in the acquisition of the inside-out gradient: (i) the expression of the protein reelin, which arrests the migration of cortical plate cells by detaching them from the radial glial fiber. This permits younger neurons to use the same fiber to migrate past the previous neurons; and (ii) the second factor is an intracellular signaling pathway dependent on a cyclin-dependent protein kinase (Cdk5). Cdk5 may work by inhibiting N-cadherin mediated cell aggregation as young cells cross the cortical plate, permitting them to move to the more superficial layers. Interestingly, the mutation in Cdk5 affects the migration of only those cells belonging to superficial layers, which are considered to be an evolutionary acquisition of the mammalian isocortex. |
| first_indexed | 2024-03-06T19:52:37Z |
| format | Journal article |
| id | oxford-uuid:2475ce51-bb96-4544-97d7-8fbd5a63c38c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:37Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:2475ce51-bb96-4544-97d7-8fbd5a63c38c2022-03-26T11:50:13ZThe inverted neurogenetic gradient of the mammalian isocortex: development and evolution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2475ce51-bb96-4544-97d7-8fbd5a63c38cEnglishSymplectic Elements at Oxford2001Aboitiz, FMorales, DMontiel, JIn this paper we review recent evidence on the molecular control of cell migration in the isocortex, and present an hypothesis for the evolutionary origin of the inside-out neurogenetic gradient of this structure. We suggest that there are at least two key factors involved in the acquisition of the inside-out gradient: (i) the expression of the protein reelin, which arrests the migration of cortical plate cells by detaching them from the radial glial fiber. This permits younger neurons to use the same fiber to migrate past the previous neurons; and (ii) the second factor is an intracellular signaling pathway dependent on a cyclin-dependent protein kinase (Cdk5). Cdk5 may work by inhibiting N-cadherin mediated cell aggregation as young cells cross the cortical plate, permitting them to move to the more superficial layers. Interestingly, the mutation in Cdk5 affects the migration of only those cells belonging to superficial layers, which are considered to be an evolutionary acquisition of the mammalian isocortex. |
| spellingShingle | Aboitiz, F Morales, D Montiel, J The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title | The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title_full | The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title_fullStr | The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title_full_unstemmed | The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title_short | The inverted neurogenetic gradient of the mammalian isocortex: development and evolution. |
| title_sort | inverted neurogenetic gradient of the mammalian isocortex development and evolution |
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