SCL/TAL1: a multifaceted regulator from blood development to disease
SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. It is required for specification of the blood program during development, adult hematopoietic stem cell survival and quiescence, and terminal matura...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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American Society of Hematology
2017
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| _version_ | 1826263495955447808 |
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| author | Porcher, C Chagraoui, H Kristiansen, M |
| author_facet | Porcher, C Chagraoui, H Kristiansen, M |
| author_sort | Porcher, C |
| collection | OXFORD |
| description | SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. It is required for specification of the blood program during development, adult hematopoietic stem cell survival and quiescence, and terminal maturation of select blood lineages. Following ectopic expression, SCL contributes to oncogenesis in T-ALL. Remarkably, SCL’s activities are all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM domain only 1 or 2]:LDB1 [LIM domain-binding protein 1]) and dynamic recruitment of conserved combinatorial associations of additional regulators in a lineage- and stage-specific context. The finely tuned control of SCL’s regulatory functions (lineage priming, activation, and repression of gene expression programs) provides insight into fundamental developmental and transcriptional mechanisms, and highlights mechanistic parallels between normal and oncogenic processes. Importantly, recent discoveries are paving the way to the development of innovative therapeutic opportunities in SCL+ T-ALL. |
| first_indexed | 2024-03-06T19:52:40Z |
| format | Journal article |
| id | oxford-uuid:247a7537-406f-437c-a03f-2175c7587c7e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:40Z |
| publishDate | 2017 |
| publisher | American Society of Hematology |
| record_format | dspace |
| spelling | oxford-uuid:247a7537-406f-437c-a03f-2175c7587c7e2022-03-26T11:50:18ZSCL/TAL1: a multifaceted regulator from blood development to diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:247a7537-406f-437c-a03f-2175c7587c7eEnglishSymplectic Elements at OxfordAmerican Society of Hematology2017Porcher, CChagraoui, HKristiansen, MSCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. It is required for specification of the blood program during development, adult hematopoietic stem cell survival and quiescence, and terminal maturation of select blood lineages. Following ectopic expression, SCL contributes to oncogenesis in T-ALL. Remarkably, SCL’s activities are all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM domain only 1 or 2]:LDB1 [LIM domain-binding protein 1]) and dynamic recruitment of conserved combinatorial associations of additional regulators in a lineage- and stage-specific context. The finely tuned control of SCL’s regulatory functions (lineage priming, activation, and repression of gene expression programs) provides insight into fundamental developmental and transcriptional mechanisms, and highlights mechanistic parallels between normal and oncogenic processes. Importantly, recent discoveries are paving the way to the development of innovative therapeutic opportunities in SCL+ T-ALL. |
| spellingShingle | Porcher, C Chagraoui, H Kristiansen, M SCL/TAL1: a multifaceted regulator from blood development to disease |
| title | SCL/TAL1: a multifaceted regulator from blood development to disease |
| title_full | SCL/TAL1: a multifaceted regulator from blood development to disease |
| title_fullStr | SCL/TAL1: a multifaceted regulator from blood development to disease |
| title_full_unstemmed | SCL/TAL1: a multifaceted regulator from blood development to disease |
| title_short | SCL/TAL1: a multifaceted regulator from blood development to disease |
| title_sort | scl tal1 a multifaceted regulator from blood development to disease |
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