T1 changes detect the progression of pathology in the white matter and cortex of MS patients

Geahča maid

• MRI brain T1 relaxation time changes in MS patients increase over time in both the white matter and the cortex.
  Dahkki: Parry, A, et al.
  Almmustuhtton: (2003)
• White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis.
  Dahkki: Parry, A, et al.
  Almmustuhtton: (2002)
• Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis.
  Dahkki: Evangelou, N, et al.
  Almmustuhtton: (2000)
• Evidence of early cortical atrophy in MS: relevance to white matter changes and disability.
  Dahkki: De Stefano, N, et al.
  Almmustuhtton: (2003)
• MS patients with chronic pain have more myelin water and less heterogeneous T1 values in normal-appearing white matter than matched MS patients without pain
  Dahkki: Kolind, S, et al.
  Almmustuhtton: (2009)