Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis
<strong>Design: <br></strong> Data from two prospective cohort studies. <br><strong>Setting and participants: <br></strong> Cohort 1 is from a single-center study involving children admitted to picu with meningococcal sepsis (samples obtained at three time p...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Diğer Yazarlar: | |
| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Wolters Kluwer Health
2021
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| _version_ | 1826311088035069952 |
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| author | Boeddha, NP Driessen, GJ Hagedoorn, NN Kohlfuerst, DS Hoggart, CJ van Rijswijk, AL Ekinci, E Priem, D Schlapbach, LJ Herberg, JA de Groot, R Anderson, ST Fink, CG Carrol, ED van der Flier, M Martinón-Torres, F Levin, M Leebeek, FW Zenz, W de Maat, MPM Hazelzet, JA Emonts, M Dik, WA Pollard, AJ |
| author2 | EUCLIDS consortium |
| author_facet | EUCLIDS consortium Boeddha, NP Driessen, GJ Hagedoorn, NN Kohlfuerst, DS Hoggart, CJ van Rijswijk, AL Ekinci, E Priem, D Schlapbach, LJ Herberg, JA de Groot, R Anderson, ST Fink, CG Carrol, ED van der Flier, M Martinón-Torres, F Levin, M Leebeek, FW Zenz, W de Maat, MPM Hazelzet, JA Emonts, M Dik, WA Pollard, AJ |
| author_sort | Boeddha, NP |
| collection | OXFORD |
| description | <strong>Design: <br></strong>
Data from two prospective cohort studies.
<br><strong>Setting and participants: <br></strong>
Cohort 1 is from a single-center study involving children admitted to picu with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission).
<br><strong>Main outcomes and measures: <br></strong>
Primary outcome measure was mortality. Secondary outcome measures were picu-free days at day 28 and hospital length of stay.
<br><strong>Results: <br></strong>
In cohort 1 (n = 59), nonsurvivors more frequently had a disintegrin and metalloproteinase with thrombospondin motifs-1 levels above the detection limit than survivors at admission to picu (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), a disintegrin and metalloproteinase with thrombospondin motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable a disintegrin and metalloproteinase with thrombospondin motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with neisseria meningitidis.
<br><strong>Conclusions and relevance: <br></strong>
In children with bacterial infection, detection of a disintegrin and metalloproteinase with thrombospondin motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs-1 and should study pathophysiologic mechanisms. |
| first_indexed | 2024-03-07T08:03:12Z |
| format | Journal article |
| id | oxford-uuid:2490f788-f52e-4ed0-b0eb-df5c467c7416 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:03:12Z |
| publishDate | 2021 |
| publisher | Wolters Kluwer Health |
| record_format | dspace |
| spelling | oxford-uuid:2490f788-f52e-4ed0-b0eb-df5c467c74162023-10-18T10:10:21ZDetectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2490f788-f52e-4ed0-b0eb-df5c467c7416EnglishSymplectic ElementsWolters Kluwer Health2021Boeddha, NPDriessen, GJHagedoorn, NNKohlfuerst, DSHoggart, CJvan Rijswijk, ALEkinci, EPriem, DSchlapbach, LJHerberg, JAde Groot, RAnderson, STFink, CGCarrol, EDvan der Flier, MMartinón-Torres, FLevin, MLeebeek, FWZenz, Wde Maat, MPMHazelzet, JAEmonts, MDik, WAPollard, AJEUCLIDS consortium<strong>Design: <br></strong> Data from two prospective cohort studies. <br><strong>Setting and participants: <br></strong> Cohort 1 is from a single-center study involving children admitted to picu with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission). <br><strong>Main outcomes and measures: <br></strong> Primary outcome measure was mortality. Secondary outcome measures were picu-free days at day 28 and hospital length of stay. <br><strong>Results: <br></strong> In cohort 1 (n = 59), nonsurvivors more frequently had a disintegrin and metalloproteinase with thrombospondin motifs-1 levels above the detection limit than survivors at admission to picu (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), a disintegrin and metalloproteinase with thrombospondin motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable a disintegrin and metalloproteinase with thrombospondin motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with neisseria meningitidis. <br><strong>Conclusions and relevance: <br></strong> In children with bacterial infection, detection of a disintegrin and metalloproteinase with thrombospondin motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs-1 and should study pathophysiologic mechanisms. |
| spellingShingle | Boeddha, NP Driessen, GJ Hagedoorn, NN Kohlfuerst, DS Hoggart, CJ van Rijswijk, AL Ekinci, E Priem, D Schlapbach, LJ Herberg, JA de Groot, R Anderson, ST Fink, CG Carrol, ED van der Flier, M Martinón-Torres, F Levin, M Leebeek, FW Zenz, W de Maat, MPM Hazelzet, JA Emonts, M Dik, WA Pollard, AJ Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title | Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title_full | Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title_fullStr | Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title_full_unstemmed | Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title_short | Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| title_sort | detectable a disintegrin and metalloproteinase with thrombospondin motifs 1 in serum is associated with adverse outcome in pediatric sepsis |
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