Engineering vanilloid-sensitivity into the rat TRPV2 channel.
The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the threshold for heat activation is extremely high (&...
| Main Authors: | , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
eLife Sciences Publications
2016
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