MicroRNA Target Identification-Experimental Approaches.
MicroRNAs (miRNAs) are small non-coding RNA molecules of 21-23 nucleotides that control gene expression at the post-transcriptional level. They have been shown to play a vital role in a wide variety of biological processes and dysregulated expression of miRNAs is observed in many pathologies. Unders...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826263545786925056 |
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| author | Martinez-Sanchez, A Murphy, C |
| author_facet | Martinez-Sanchez, A Murphy, C |
| author_sort | Martinez-Sanchez, A |
| collection | OXFORD |
| description | MicroRNAs (miRNAs) are small non-coding RNA molecules of 21-23 nucleotides that control gene expression at the post-transcriptional level. They have been shown to play a vital role in a wide variety of biological processes and dysregulated expression of miRNAs is observed in many pathologies. Understanding the mechanism of action and identifying functionally important mRNA targets of a specific miRNA are essential to unravelling its biological function and to assist miRNA-based drug development. This review summarizes the current understanding of the mechanistic aspects of miRNA-mediated gene repression and focuses on the different approaches for miRNA target identification that have been proposed in recent years. |
| first_indexed | 2024-03-06T19:53:29Z |
| format | Journal article |
| id | oxford-uuid:24c408d0-6a60-4608-aed4-6ad3b1943e04 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:53:29Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:24c408d0-6a60-4608-aed4-6ad3b1943e042022-03-26T11:51:53ZMicroRNA Target Identification-Experimental Approaches.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24c408d0-6a60-4608-aed4-6ad3b1943e04EnglishSymplectic Elements at Oxford2013Martinez-Sanchez, AMurphy, CMicroRNAs (miRNAs) are small non-coding RNA molecules of 21-23 nucleotides that control gene expression at the post-transcriptional level. They have been shown to play a vital role in a wide variety of biological processes and dysregulated expression of miRNAs is observed in many pathologies. Understanding the mechanism of action and identifying functionally important mRNA targets of a specific miRNA are essential to unravelling its biological function and to assist miRNA-based drug development. This review summarizes the current understanding of the mechanistic aspects of miRNA-mediated gene repression and focuses on the different approaches for miRNA target identification that have been proposed in recent years. |
| spellingShingle | Martinez-Sanchez, A Murphy, C MicroRNA Target Identification-Experimental Approaches. |
| title | MicroRNA Target Identification-Experimental Approaches. |
| title_full | MicroRNA Target Identification-Experimental Approaches. |
| title_fullStr | MicroRNA Target Identification-Experimental Approaches. |
| title_full_unstemmed | MicroRNA Target Identification-Experimental Approaches. |
| title_short | MicroRNA Target Identification-Experimental Approaches. |
| title_sort | microrna target identification experimental approaches |
| work_keys_str_mv | AT martinezsancheza micrornatargetidentificationexperimentalapproaches AT murphyc micrornatargetidentificationexperimentalapproaches |