SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore the interaction of Srsf2P95H with Jak2V617F,...

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Bibliographic Details
Main Authors: Willekens, C, Laplane, L, Dagher, T, Benlabiod, C, Papadopoulos, N, Lacout, C, Rameau, P, Catelain, C, Alfaro, A, Edmond, V, Signolle, N, Marchand, V, Droin, N, Hoogenboezem, R, Schneider, RK, Penson, A, Abdel-Wahab, O, Giraudier, S, Pasquier, F, Marty, C, Plo, I, Villeval, J-L, Constantinescu, SN, Porteu, F, Vainchenker, W, Solary, E
Format: Journal article
Language:English
Published: Springer Nature 2023

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