High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South...

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Detalles Bibliográficos
Autores principales: Mentzer, AJ, Dilthey, AT, Pollard, M, Gurdasani, D, Karakoc, E, Carstensen, T, Muhwezi, A, Cutland, C, Diarra, A, da Silva Antunes, R, Paul, S, Smits, G, Wareing, S, Kim, H, Pomilla, C, Chong, AY, Brandt, DYC, Nielsen, R, Neaves, S, Timpson, N, Crinklaw, A, Lindestam Arlehamn, CS, Rautanen, A, Kizito, D, Parks, T, Auckland, K, Elliott, KE, Mills, T, Ewer, K, Edwards, N, Jeffery, K, McVean, G, Hill, AVS
Formato: Journal article
Lenguaje:English
Publicado: Nature Research 2024

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