High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South...

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Prif Awduron: Mentzer, AJ, Dilthey, AT, Pollard, M, Gurdasani, D, Karakoc, E, Carstensen, T, Muhwezi, A, Cutland, C, Diarra, A, da Silva Antunes, R, Paul, S, Smits, G, Wareing, S, Kim, H, Pomilla, C, Chong, AY, Brandt, DYC, Nielsen, R, Neaves, S, Timpson, N, Crinklaw, A, Lindestam Arlehamn, CS, Rautanen, A, Kizito, D, Parks, T, Auckland, K, Elliott, KE, Mills, T, Ewer, K, Edwards, N, Jeffery, K, McVean, G, Hill, AVS
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Nature Research 2024

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