High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South...

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Détails bibliographiques
Auteurs principaux:	Mentzer, AJ, Dilthey, AT, Pollard, M, Gurdasani, D, Karakoc, E, Carstensen, T, Muhwezi, A, Cutland, C, Diarra, A, da Silva Antunes, R, Paul, S, Smits, G, Wareing, S, Kim, H, Pomilla, C, Chong, AY, Brandt, DYC, Nielsen, R, Neaves, S, Timpson, N, Crinklaw, A, Lindestam Arlehamn, CS, Rautanen, A, Kizito, D, Parks, T, Auckland, K, Elliott, KE, Mills, T, Ewer, K, Edwards, N, Jeffery, K, McVean, G, Hill, AVS
Format:	Journal article
Langue:	English
Publié:	Nature Research 2024

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

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