N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors

N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors

17β‐Hydroxysteroid dehydrogenases act at the pre‐receptor level, catalysing interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less active estrone to estradiol and i...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Mottinelli, M, Sinreh, M, Rižner, TL, Leese, MP, Potter, BVL
פורמט:	Journal article
שפה:	English
יצא לאור:	Wiley 2020

פריטים דומים

Synthesis and characterization of metal dithiocarbamate derivatives of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
מאת: Azim Ziyaei Halimehjani, et al.
יצא לאור: (2024-11-01)

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz-Fritsch-Bobbitt reaction with non-activated and moderately-activated systems
מאת: Mottinelli, M, et al.
יצא לאור: (2017)

TETRAHYDROISOQUINOLINES .4. ENANTIOSELECTIVE CONVERSION OF (+)-AMPHETAMINE INTO (+)-(1R,3S,4S)-1,2,3,4-TETRAMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND (-)-(1S,3S,4R)-1,2,3,4-TETRAMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE VIA TRICARBONYL(ARENE)CHROMIUM METHODOLOGY
מאת: Coote, S, et al.
יצא לאור: (1988)

TETRAHYDROISOQUINOLINES .2. SYNTHESIS OF 4-SUBSTITUTED N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINES VIA REGIOSELECTIVE AND STEREOSELECTIVE ELABORATION OF TRICARBONYL(N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE)CHROMIUM
מאת: Blagg, J, et al.
יצא לאור: (1986)

4-SUBSTITUTED N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINES - SYNTHESIS VIA STEREOSELECTIVE SUBSTITUTION OF TRICARBONYL(N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE)CHROMIUM
מאת: Blagg, J, et al.
יצא לאור: (1985)

{(1R,3S)-2-Benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl}diphenylmethanol
מאת: Glenn E.M. Maguire, et al.
יצא לאור: (2010-03-01)

Enantiospecific stereodivergent synthesis of trans- and cis-N(2),3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolines.
מאת: Coote, S, et al.
יצא לאור: (2010)

N-(Adamantan-1-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide
מאת: Hoong-Kun Fun, et al.
יצא לאור: (2013-12-01)

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carbothioamide
מאת: Tricia Naicker, et al.
יצא לאור: (2011-12-01)

TETRAHYDROISOQUINOLINES .3. STEREOSELECTIVE SYNTHESIS OF CIS- AND TRANS-1,4-DISUBSTITUTED N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINES AS THEIR TRICARBONYLCHROMIUM COMPLEXES
מאת: Blagg, J, et al.
יצא לאור: (1987)

Practical and Efficient Synthesis of α-Aminophosphonic Acids Containing 1,2,3,4-Tetrahydroquinoline or 1,2,3,4-Tetrahydroisoquinoline Heterocycles
מאת: Mario Ordóñez, et al.
יצא לאור: (2016-08-01)

The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats
מאת: Abdullah, Aszrin, et al.
יצא לאור: (2011)

ENANTIOSPECIFIC SYNTHESIS OF (+)-(R)-6,7-DIMETHOXY-2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE FROM (+)-(S)-2-METHYLAMINO-1-PHENYLETHANOL (HALOSTACHINE)
מאת: Coote, S, et al.
יצא לאור: (1989)

STEREOCONTROLLED SYNTHESIS OF N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES VIA CHROMIUM TRICARBONYL METHODOLOGIES
מאת: Davies, S
יצא לאור: (1990)

Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives
מאת: Maria Chrzanowska, et al.
יצא לאור: (2023-04-01)

One-pot synthesis of some N-benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines using benzotriazole auxiliary
מאת: Cornelia Locher, et al.
יצא לאור: (2000-02-01)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
מאת: Gathercole, L, et al.
יצא לאור: (2013)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
מאת: Wiegand, S, et al.
יצא לאור: (2007)

Aziridines and aziridinium intermediates in the asymmetric synthesis of beta-substituted-alpha-amino acids and 1,2,3,4-tetrahydroisoquinolines
מאת: Frost, A
יצא לאור: (2015)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
מאת: Lukacik, P, et al.
יצא לאור: (2006)

Methyl trans-rac-2-hexyl-1-oxo-3-(2-pyridyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylate
מאת: Orhan Büyükgüngör, et al.
יצא לאור: (2008-10-01)

In vitro screening of 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines: Structure related activity against pathogenic bacteria
מאת: Moses Njutain Ngemenya, et al.
יצא לאור: (2015-06-01)

Crystal structure of 3-(benzhydrylcarbamoyl)-2-benzyl-6,7-dimethoxy-1- phenyl-1,2,3,4-tetrahydroisoquinoline 2-oxide, C38H36N2O4
מאת: Francis Vivian, et al.
יצא לאור: (2014-12-01)

Sustained blood pressure reduction with chronic 1,2,3,4- tetrahydroisoquinolines administration in young adult, spontaneously hypertensive rats
מאת: Abdullah, Aszrin, et al.
יצא לאור: (2011)

One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline
מאת: Jiawei Niu, et al.
יצא לאור: (2024-04-01)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
מאת: Stewart, P, et al.
יצא לאור: (2002)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
מאת: Maser, E, et al.
יצא לאור: (1997)

Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).
מאת: Alessandro Spadaro, et al.
יצא לאור: (2012-01-01)

Crystal structure of (S)-N-benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, C17H20N2O2
מאת: Cele Zamani E. D., et al.
יצא לאור: (2013-10-01)

17β-hydroxysteroid dehydrogenase type 1 improves survival in serous epithelial ovarian tumors
מאת: Enrique Pedernera, et al.
יצא לאור: (2023-11-01)

Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from alpha-hydroxy-beta-amino esters
מאת: Davies, S, et al.
יצא לאור: (2016)

Crystal structure of 1,2,3,4-tetrahydroisoquinolin-2-ium (2S,3S)-3-carboxy-2,3-dihydroxypropanoate monohydrate
מאת: Rüdiger W. Seidel, et al.
יצא לאור: (2024-07-01)

trans-rac-[1-Oxo-2-phenethyl-3-(2-thienyl)-1,2,3,4-tetrahydroisoquinolin-4-yl]methyl 4-methylbenzenesulfonate
מאת: Orhan Büyükgüngör, et al.
יצא לאור: (2008-10-01)

Methyl trans-(&#177;)-1-oxo-2-phenethyl-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylate
מאת: Mehmet Akkurt, et al.
יצא לאור: (2009-06-01)

Structure-function relationships of SDR hydroxysteroid dehydrogenases.
מאת: Oppermann, U, et al.
יצא לאור: (1997)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
מאת: Katarzyna Kosicka, et al.
יצא לאור: (2016-01-01)

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
מאת: Heidi L. Doden, et al.
יצא לאור: (2021-02-01)

Expression of gluconeogenic enzymes and 11β-hydroxysteroid dehydrogenase type 1 in liver of diabetic mice after acute exercise
מאת: Brust KB, et al.
יצא לאור: (2014-10-01)

N-Phenyl-2-(1,2,3,4-tetrahydronaphthalen-1-ylidene)hydrazinecarbothioamide
מאת: Adriano Bof de Oliveira, et al.
יצא לאור: (2014-02-01)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
מאת: Wiegand, S, et al.
יצא לאור: (2007)