N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors
17β‐Hydroxysteroid dehydrogenases act at the pre‐receptor level, catalysing interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less active estrone to estradiol and i...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
Wiley
2020
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