Cavitation-enhanced delivery of macromolecules into an obstructed vessel.
Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model...
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2010
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| _version_ | 1826263564055216128 |
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| author | Rifai, B Arvanitis, C Bazan-Peregrino, M Coussios, C |
| author_facet | Rifai, B Arvanitis, C Bazan-Peregrino, M Coussios, C |
| author_sort | Rifai, B |
| collection | OXFORD |
| description | Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring. |
| first_indexed | 2024-03-06T19:53:47Z |
| format | Journal article |
| id | oxford-uuid:24d97afa-366f-4093-896b-1a0a32484ddb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:53:47Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:24d97afa-366f-4093-896b-1a0a32484ddb2022-03-26T11:52:25ZCavitation-enhanced delivery of macromolecules into an obstructed vessel.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24d97afa-366f-4093-896b-1a0a32484ddbEnglishSymplectic Elements at Oxford2010Rifai, BArvanitis, CBazan-Peregrino, MCoussios, CPoor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring. |
| spellingShingle | Rifai, B Arvanitis, C Bazan-Peregrino, M Coussios, C Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title | Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title_full | Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title_fullStr | Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title_full_unstemmed | Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title_short | Cavitation-enhanced delivery of macromolecules into an obstructed vessel. |
| title_sort | cavitation enhanced delivery of macromolecules into an obstructed vessel |
| work_keys_str_mv | AT rifaib cavitationenhanceddeliveryofmacromoleculesintoanobstructedvessel AT arvanitisc cavitationenhanceddeliveryofmacromoleculesintoanobstructedvessel AT bazanperegrinom cavitationenhanceddeliveryofmacromoleculesintoanobstructedvessel AT coussiosc cavitationenhanceddeliveryofmacromoleculesintoanobstructedvessel |