The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.

The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.

We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappe...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Hindmarsh, P, Matthews, DR, Brain, C, Pringle, P, di Silvio, L, Kurtz, AB, Brook, C
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 1989
Περιγραφή
Περίληψη:We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates.

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