The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.
We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappe...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797058685786128384 |
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| author | Hindmarsh, P Matthews, DR Brain, C Pringle, P di Silvio, L Kurtz, AB Brook, C |
| author_facet | Hindmarsh, P Matthews, DR Brain, C Pringle, P di Silvio, L Kurtz, AB Brook, C |
| author_sort | Hindmarsh, P |
| collection | OXFORD |
| description | We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates. |
| first_indexed | 2024-03-06T19:53:47Z |
| format | Journal article |
| id | oxford-uuid:24d99c64-61c0-43c4-aa70-b3752ab3da5a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:53:47Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:24d99c64-61c0-43c4-aa70-b3752ab3da5a2022-03-26T11:52:27ZThe half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24d99c64-61c0-43c4-aa70-b3752ab3da5aEnglishSymplectic Elements at Oxford1989Hindmarsh, PMatthews, DRBrain, CPringle, Pdi Silvio, LKurtz, ABBrook, CWe have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates. |
| spellingShingle | Hindmarsh, P Matthews, DR Brain, C Pringle, P di Silvio, L Kurtz, AB Brook, C The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title | The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title_full | The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title_fullStr | The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title_full_unstemmed | The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title_short | The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. |
| title_sort | half life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin |
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