Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane
Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a sub...
| المؤلفون الرئيسيون: | , , , |
|---|---|
| التنسيق: | Journal article |
| منشور في: |
Cell Press
2018
|
| _version_ | 1826263571345965056 |
|---|---|
| author | Taylor, R Heine, M Emptage, N Andreae, L |
| author_facet | Taylor, R Heine, M Emptage, N Andreae, L |
| author_sort | Taylor, R |
| collection | OXFORD |
| description | Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity. |
| first_indexed | 2024-03-06T19:53:54Z |
| format | Journal article |
| id | oxford-uuid:24e1ee65-91fb-45b9-aed6-d0c4cfd6c9aa |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:53:54Z |
| publishDate | 2018 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:24e1ee65-91fb-45b9-aed6-d0c4cfd6c9aa2022-03-26T11:52:39ZNeuronal receptors display cytoskeleton-independent directed motion on the plasma membraneJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24e1ee65-91fb-45b9-aed6-d0c4cfd6c9aaSymplectic Elements at OxfordCell Press2018Taylor, RHeine, MEmptage, NAndreae, LDirected transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity. |
| spellingShingle | Taylor, R Heine, M Emptage, N Andreae, L Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title | Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title_full | Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title_fullStr | Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title_full_unstemmed | Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title_short | Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane |
| title_sort | neuronal receptors display cytoskeleton independent directed motion on the plasma membrane |
| work_keys_str_mv | AT taylorr neuronalreceptorsdisplaycytoskeletonindependentdirectedmotionontheplasmamembrane AT heinem neuronalreceptorsdisplaycytoskeletonindependentdirectedmotionontheplasmamembrane AT emptagen neuronalreceptorsdisplaycytoskeletonindependentdirectedmotionontheplasmamembrane AT andreael neuronalreceptorsdisplaycytoskeletonindependentdirectedmotionontheplasmamembrane |