Linkage disequilibrium under skewed offspring distribution among individuals in a population.
Correlations in coalescence times between two loci are derived under selectively neutral population models in which the offspring of an individual can number on the order of the population size. The correlations depend on the rates of recombination and random drift and are shown to be functions of t...
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797058694093996032 |
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| author | Eldon, B Wakeley, J |
| author_facet | Eldon, B Wakeley, J |
| author_sort | Eldon, B |
| collection | OXFORD |
| description | Correlations in coalescence times between two loci are derived under selectively neutral population models in which the offspring of an individual can number on the order of the population size. The correlations depend on the rates of recombination and random drift and are shown to be functions of the parameters controlling the size and frequency of these large reproduction events. Since a prediction of linkage disequilibrium can be written in terms of correlations in coalescence times, it follows that the prediction of linkage disequilibrium is a function not only of the rate of recombination but also of the reproduction parameters. Low linkage disequilibrium is predicted if the offspring of a single individual frequently replace almost the entire population. However, high linkage disequilibrium can be predicted if the offspring of a single individual replace an intermediate fraction of the population. In some cases the model reproduces the standard Wright-Fisher predictions. Contrary to common intuition, high linkage disequilibrium can be predicted despite frequent recombination, and low linkage disequilibrium under infrequent recombination. Simulations support the analytical results but show that the variance of linkage disequilibrium is very large. |
| first_indexed | 2024-03-06T19:53:54Z |
| format | Journal article |
| id | oxford-uuid:24e26b33-0621-4bff-b978-5f3d504dd2b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:53:54Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:24e26b33-0621-4bff-b978-5f3d504dd2b02022-03-26T11:52:39ZLinkage disequilibrium under skewed offspring distribution among individuals in a population.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:24e26b33-0621-4bff-b978-5f3d504dd2b0EnglishSymplectic Elements at Oxford2008Eldon, BWakeley, JCorrelations in coalescence times between two loci are derived under selectively neutral population models in which the offspring of an individual can number on the order of the population size. The correlations depend on the rates of recombination and random drift and are shown to be functions of the parameters controlling the size and frequency of these large reproduction events. Since a prediction of linkage disequilibrium can be written in terms of correlations in coalescence times, it follows that the prediction of linkage disequilibrium is a function not only of the rate of recombination but also of the reproduction parameters. Low linkage disequilibrium is predicted if the offspring of a single individual frequently replace almost the entire population. However, high linkage disequilibrium can be predicted if the offspring of a single individual replace an intermediate fraction of the population. In some cases the model reproduces the standard Wright-Fisher predictions. Contrary to common intuition, high linkage disequilibrium can be predicted despite frequent recombination, and low linkage disequilibrium under infrequent recombination. Simulations support the analytical results but show that the variance of linkage disequilibrium is very large. |
| spellingShingle | Eldon, B Wakeley, J Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title | Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title_full | Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title_fullStr | Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title_full_unstemmed | Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title_short | Linkage disequilibrium under skewed offspring distribution among individuals in a population. |
| title_sort | linkage disequilibrium under skewed offspring distribution among individuals in a population |
| work_keys_str_mv | AT eldonb linkagedisequilibriumunderskewedoffspringdistributionamongindividualsinapopulation AT wakeleyj linkagedisequilibriumunderskewedoffspringdistributionamongindividualsinapopulation |