Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
Mathematical models of ion channels, which constitute indispensable components of action potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a previous study, we fitted cell-specific models to hERG1a (Kv11.1) recordings simultaneously measured using an automated...
Main Authors: | Lei, CL, Clerx, M, Whittaker, D, Gavaghan, DJ, de Boer, TP, Mirams, GR |
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Format: | Journal article |
Language: | English |
Published: |
Royal Society
2020
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