A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells.

A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells.

We have engineered an anti-carcinoembryonic antigen (CEA) single-chain immunotoxin derived from humanized anti-CEA antibody (hMN14) and a truncated Pseudomonas exotoxin (PE), PE40. The purified anti-CEA immunotoxin (hMN14(Fv)-PE40) was first measured for binding affinity against a CEA-positive color...

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Bibliographic Details
Main Authors:	Akamatsu, Y, Murphy, J, Nolan, K, Thomas, P, Kreitman, R, Leung, S, Junghans, R
Format:	Journal article
Language:	English
Published:	1998

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