The where and when of T cell regulation in transplantation.
Multiple cell types contribute to the peripheral regulation of T cell alloresponses in haematopoieitc cell transplantation (HCT) and solid organ transplantation (SOT). Of these, regulatory T cells (Tregs) are the principal players and have shown the greatest success in the therapeutic control of det...
| Main Authors: | , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2013
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| _version_ | 1826263603354796032 |
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| author | Issa, F Robb, R Wood, K |
| author_facet | Issa, F Robb, R Wood, K |
| author_sort | Issa, F |
| collection | OXFORD |
| description | Multiple cell types contribute to the peripheral regulation of T cell alloresponses in haematopoieitc cell transplantation (HCT) and solid organ transplantation (SOT). Of these, regulatory T cells (Tregs) are the principal players and have shown the greatest success in the therapeutic control of detrimental immune responses. Investigations into the induction, location, and mechanism of suppression utilised by Tregs to control alloreactive responses are ongoing. The activation and homing characteristics of Tregs are important to their regulatory capabilities, with activation and homing occurring in the same time and space as conventional T cells. This review discusses these characteristics and recent advances in the field as we move closer to the ultimate goal of utilising Tregs as treatment for allograft rejection and graft-versus-host disease (GvHD). |
| first_indexed | 2024-03-06T19:54:24Z |
| format | Journal article |
| id | oxford-uuid:25102a49-e4cd-4102-bfce-4e9c7fa59bdb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:54:24Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:25102a49-e4cd-4102-bfce-4e9c7fa59bdb2022-03-26T11:53:36ZThe where and when of T cell regulation in transplantation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25102a49-e4cd-4102-bfce-4e9c7fa59bdbEnglishSymplectic Elements at Oxford2013Issa, FRobb, RWood, KMultiple cell types contribute to the peripheral regulation of T cell alloresponses in haematopoieitc cell transplantation (HCT) and solid organ transplantation (SOT). Of these, regulatory T cells (Tregs) are the principal players and have shown the greatest success in the therapeutic control of detrimental immune responses. Investigations into the induction, location, and mechanism of suppression utilised by Tregs to control alloreactive responses are ongoing. The activation and homing characteristics of Tregs are important to their regulatory capabilities, with activation and homing occurring in the same time and space as conventional T cells. This review discusses these characteristics and recent advances in the field as we move closer to the ultimate goal of utilising Tregs as treatment for allograft rejection and graft-versus-host disease (GvHD). |
| spellingShingle | Issa, F Robb, R Wood, K The where and when of T cell regulation in transplantation. |
| title | The where and when of T cell regulation in transplantation. |
| title_full | The where and when of T cell regulation in transplantation. |
| title_fullStr | The where and when of T cell regulation in transplantation. |
| title_full_unstemmed | The where and when of T cell regulation in transplantation. |
| title_short | The where and when of T cell regulation in transplantation. |
| title_sort | where and when of t cell regulation in transplantation |
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