Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

The regulation of stem cell ontogeny is poorly understood. We show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells (HSCs) in the dorsal aorta (DA). In contrast, Tel1/ETV6 has little effect on embryonic blood formation, further distinguis...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Ciau-Uitz, A, Pinheiro, P, Gupta, R, Enver, T, Patient, R
Format:	Journal article
Język:	English
Wydane:	2010

Podobne zapisy

ETV6/TEL1 is required for HSC embryonic development
od: Pinheiro, P, i wsp.
Wydane: (2005)

Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
od: Li, L, i wsp.
Wydane: (2019)

Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
od: Lei Li, i wsp.
Wydane: (2019-03-01)

Notch input to blood stem cell programming during Xenopus ontogeny
od: Stephenson, R, i wsp.
Wydane: (2011)

Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage
od: Kirmizitas, A, i wsp.
Wydane: (2017)

The embryonic origins and genetic programming of emerging haematopoietic stem cells
od: Ciau-Uitz, A, i wsp.
Wydane: (2016)

Gene regulatory networks governing the generation and regeneration of blood
od: Ciau-Uitz, A, i wsp.
Wydane: (2019)

ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish
od: Parisa Rasighaemi, i wsp.
Wydane: (2015-01-01)

VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.
od: Ciau-Uitz, A, i wsp.
Wydane: (2013)

Programming haematopoietic stem cells in the embryonic dorsal aorta
od: Ciau-Uitz, A, i wsp.
Wydane: (2007)

Programming of HSCs during development
od: Ciau-Uitz, A, i wsp.
Wydane: (2007)

Distinct origins of adult and embryonic blood in Xenopus.
od: Ciau-Uitz, A, i wsp.
Wydane: (2000)

Adult and embryonic blood and endothelium derive from distinct precursor populations which are differentially programmed by BMP in Xenopus.
od: Walmsley, M, i wsp.
Wydane: (2002)

ETS transcription factors in hematopoietic stem cell development
od: Ciau-Uitz, A, i wsp.
Wydane: (2013)

ETS transcription factors in hematopoietic stem cell development
od: Ciau-Uitz, A, i wsp.
Wydane: (2013)

On the development of embryonic hematopoietic and endothelial cells in Xenopus.
od: Ciau-Uitz, A, i wsp.
Wydane: (2004)

LLA em portadores de Síndrome de Down e TEL/AML1(ETV6/RUNX1) Acute lymphoblastic leukemia in Down syndrome and TEL/AML1(ETV6/RUNX1)
od: Maria de Lourdes L. F. Chauffaille
Wydane: (2009-01-01)

Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis.
od: Eguchi-Ishimae, M, i wsp.
Wydane: (2009)

The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.
od: Pavithra Vivekanand, i wsp.
Wydane: (2012-01-01)

GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
od: Afouda, B, i wsp.
Wydane: (2005)

CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX
od: Aldo Ciau-Uitz, i wsp.
Wydane: (2017)

VEGF/Flk1 signaling cascade transactivates Etv2 gene expression.
od: Tara L Rasmussen, i wsp.
Wydane: (2012-01-01)

Origins and programming of hematopoietic stem cells in fish and frog embryos.
od: Ciau-Uitz, A, i wsp.
Wydane: (2000)

Genetic control of hematopoietic development in Xenopus and zebrafish.
od: Ciau-Uitz, A, i wsp.
Wydane: (2010)

Tracking and programming early hematopoietic cells in Xenopus embryos.
od: Walmsley, M, i wsp.
Wydane: (2005)

VEGFA Controls Haematopoietic Stem Cell Specification In a Dose-Dependent, Isoform-Specific Manner
od: Leung, A, i wsp.
Wydane: (2010)

GATA transcription factors integrate Wnt signalling during heart development.
od: Afouda, B, i wsp.
Wydane: (2008)

Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification.
od: Leung, A, i wsp.
Wydane: (2013)

Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification
od: Leung, A, i wsp.
Wydane: (2013)

Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion.
od: Christian Kreis, i wsp.
Wydane: (2017-01-01)

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny.
od: Nimmo, R, i wsp.
Wydane: (2013)

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny
od: Nimmo, R, i wsp.
Wydane: (2013)

Developmental hematopoiesis: ontogeny, genetic programming and conservation.
od: Ciau-Uitz, A, i wsp.
Wydane: (2014)

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
od: Göttgens, B, i wsp.
Wydane: (2002)

The origins and programming of adult and embryonic blood in xenopus and zebrafish.
od: Patient, R, i wsp.
Wydane: (2003)

Adult red cells are programmed completely independently of embryonic red cells during development.
od: Gering, M, i wsp.
Wydane: (2005)

New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images
od: Patrushev, I, i wsp.
Wydane: (2018)

ETV in Singapore
od: Ng, Sin Yue
Wydane: (2008)

The practice of ETV/
od: 281796 Gibson, Tony
Wydane: (1970)

Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos.
od: Gering, M, i wsp.
Wydane: (2005)