Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats.
To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the genomic background of MuV(JL5) Cross-reactivity and cross-neutralization between this chimeric rMuV(...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2016
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| _version_ | 1797058782117756928 |
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| author | Beaty, S Nachbagauer, R Hirsh, A Vigant, F Duehr, J Azarm, K Stelfox, A Bowden, T Duprex, W Krammer, F Lee, B |
| author_facet | Beaty, S Nachbagauer, R Hirsh, A Vigant, F Duehr, J Azarm, K Stelfox, A Bowden, T Duprex, W Krammer, F Lee, B |
| author_sort | Beaty, S |
| collection | OXFORD |
| description | To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the genomic background of MuV(JL5) Cross-reactivity and cross-neutralization between this chimeric rMuV(JL5)-F/HN(BMV) virus and rMuV(JL5) were demonstrated using hyperimmune mouse sera and a curated panel of human sera. All mouse and human sera that were able to neutralize rMuV(JL5) infection had cross-neutralizing activity against rMuV(JL5)-F/HN(BMV) Our data suggests that people who have neutralizing antibodies against MuV might be protected from infection by BMV. |
| first_indexed | 2024-03-06T19:55:12Z |
| format | Journal article |
| id | oxford-uuid:25528a22-e4fe-44c0-9698-570b6a25b8a0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:55:12Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:25528a22-e4fe-44c0-9698-570b6a25b8a02022-03-26T11:55:04ZCross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25528a22-e4fe-44c0-9698-570b6a25b8a0EnglishSymplectic Elements at OxfordOxford University Press2016Beaty, SNachbagauer, RHirsh, AVigant, FDuehr, JAzarm, KStelfox, ABowden, TDuprex, WKrammer, FLee, BTo evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the genomic background of MuV(JL5) Cross-reactivity and cross-neutralization between this chimeric rMuV(JL5)-F/HN(BMV) virus and rMuV(JL5) were demonstrated using hyperimmune mouse sera and a curated panel of human sera. All mouse and human sera that were able to neutralize rMuV(JL5) infection had cross-neutralizing activity against rMuV(JL5)-F/HN(BMV) Our data suggests that people who have neutralizing antibodies against MuV might be protected from infection by BMV. |
| spellingShingle | Beaty, S Nachbagauer, R Hirsh, A Vigant, F Duehr, J Azarm, K Stelfox, A Bowden, T Duprex, W Krammer, F Lee, B Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title | Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title_full | Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title_fullStr | Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title_full_unstemmed | Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title_short | Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats. |
| title_sort | cross reactive and cross neutralizing activity of human mumps antibodies against a novel mumps virus from bats |
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