Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery of a potent and selective DDR1 inhibitor, DDR1-IN-1, and present the 2.2 Å...
Main Authors: | Kim, H, Tan, L, Weisberg, E, Liu, F, Canning, P, Choi, H, Ezell, SA, Wu, H, Zhao, Z, Wang, J, Mandinova, A, Griffin, J, Bullock, A, Liu, Q, Lee, S, Gray, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2013
|
Similar Items
-
Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor.
by: Kim, H, et al.
Published: (2014) -
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
by: Canning, P, et al.
Published: (2014) -
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors
by: Canning, P, et al.
Published: (2014) -
Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton’s Tyrosine Kinase
by: Eun Lee, et al.
Published: (2020-10-01) -
Molecular Drug Discovery of Single Ginsenoside Compounds as a Potent Bruton’s Tyrosine Kinase Inhibitor
by: Keun Woo Lee, et al.
Published: (2020-04-01)